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# that'd be
sickle cell

if you're a carrier of the gene then you're protected against malaria, however if you've got two copies of it you've got an incredibly painful (and terminal if i remember correctly) blood disease, it's not a great mutation to have.

although, i get the point that the developing world isn't benefiting from the advancement of the human race, but i'd say that aid agencies and civil wars are still preventing evolution
(, Sun 3 Jun 2007, 15:41, archived)